Recombinant Anti-MTAP Antibody [MTAP/3137R] (A249390)

Anti-MTAP Antibody [MTAP/3137R]

Recombinant rabbit monoclonal [MTAP/3137R] antibody to MTAP.

This antibody recognizes a protein of 31kDa, which is identified as MTAP (5'-deoxy-5'-methylthioadenosine phosphorylase). It catalyzes the reversible phosphorolysis of methylthioadenosine, which is important in polyamine metabolism and for the salvage of adenine and methionine. The gene encoding MTAP is linked to the tumor suppressor gene, p16INK4A. Deficient levels of MTAP can occur in cancers primarily through co-deletion of the MTAP gene and the p16INK4A gene. Cells expressing MTAP and possessing adenine salvage pathway activity may be less susceptible to malignancy due to growth-inhibitory actions of agents (e.g. antifolates), whose mechanism of action, in part, involves this de novo purine pathway.

ELISA, WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 97-196, of human MTAP protein. The exact sequence is proprietary.

Rabbit

Monoclonal

MTAP/3137R

IgG

Protein A/G chromatography.

200 µg/ml

31 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MTAP Antibody [MTAP/3137R] - BSA and Azide free (A252570).

5'-methylthioadenosine phosphorylase, MSAP, MTA phosphorylase, MTAPase, S-methyl-5'-thioadenosine phosphorylase