Anti-MR1 Antibody [MR1/7577] (A315328)

Anti-MR1 Antibody [MR1/7577]

Mouse monoclonal [MR1/7577] antibody to MR1.

MR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.

Human kidney, placenta or tonsil.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 50-250) of human MR1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

MR1/7577

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

39 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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