Anti-MMP3 Antibody [1B4] (A249367)

Anti-MMP3 Antibody [1B4]

Mouse monoclonal [1B4] antibody to MMP3.

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

ELISA: 2-4 µg/ml

Human

Recombinant fragment, corresponding to amino acids 317-327, of human MMP3 protein.

Mouse

Monoclonal

1B4

IgG3

Unconjugated

Protein A chromatography.

200 µg/ml

57 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Store at 4°C.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MMP3 Antibody [1B4] - BSA and Azide free (A252547).

CHDS6, Matrix metalloproteinase 3, Matrix metalloproteinase-3, MGC126102, MGC126103, MGC126104, MMP 3, MMP-3, MMP3_HUMAN, Proteoglycanase , SL-1, SL1 , STMY, STMY1, STR1, Stromelysin 1, Stromelysin-1, Transin 1, Transin-1