Anti-MIF Antibody [MIF/3489] (A277707)

Anti-MIF Antibody [MIF/3489]

Mouse monoclonal [MIF/3489] antibody to MIF.

Macrophage migration inhibitory factor, known as MIF or glycosylationinhibiting factor, is a secreted, homotrimeric, pro-inflammatory cytokine that modulates macrophage and T cell function and is an important regulator of host response to infection. MIF is expressed at sites of inflammation, which suggests that it plays a role in regulating macrophage function in host defense. MIF is produced by the pituitary gland and is found in monocytes, macrophages, differentiating immunological cells in the eye lens and brain, and fibroblasts. Elevated levels of MIF protein are detected in the plasma of patients with severe sepsis or septic shock, a condition where MIF influences endotoxic shock by enhancing the production of other inflammatory cytokines including tumor necrosis factor α (TNFα), interleukin-1 (IL-1) and interferon-γ (IFN-γ). MIF promotes the systemic inflammatory response by counter-regulating glucocorticoid-mediated inhibition of immune-cell activation and proinflammatory cytokine production. MIF may mediate tissue destruction through the induction of proteinases.

WB, IHC-P

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

Recombinant fragment corresponding to human MIF protein. The exact sequence is proprietary.

Mouse

Monoclonal

MIF/3489

IgG2a

Unconjugated

Protein A/G chromatography.

200 µg/ml

13 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MIF Antibody [MIF/3489] - BSA and Azide free (A278295).

GIF, GLIF, Glycosylation inhibiting factor, Glycosylation-inhibiting factor, L-dopachrome isomerase, L-dopachrome tautomerase, Macrophage migration inhibitory factor, Macrophage migration inhibitory factor (glycosylation-inhibiting factor), MIF protein, MIF_HUMAN, MMIF, Phenylpyruvate tautomerase