Recombinant Anti-MDM2 Antibody [MDM2/7189R] - BSA and Azide free (A316677)

Anti-MDM2 Antibody [MDM2/7189R] - BSA and Azide free

Recombinant rabbit monoclonal [MDM2/7189R] antibody to MDM2.

MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.

Human liposarcoma.

IHC: 1-2 µg/ml

Human

Recombinant human MDM2 protein fragment. The exact sequence is proprietary.

Rabbit

Monoclonal

MDM2/7189R

IgG

Protein A/G chromatography.

1 mg/ml

~90 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2