Anti-MCL1 Antibody (A283996)

Anti-MCL1 Antibody

Rabbit polyclonal antibody to MCL1.

This antibody recognises an epitope within the central region (IN) of human Myeloid cell leukaemia sequence 1 (MCL-1), an anti-apoptotic member of the Bcl-2 family of proteins, first identified in differentiating ML-1 myeloid cells, and expressed in many different cell lines, tissues and a variety of tumours.The MCL-1 protein, localised to intracellular membranes and particularly mitochondrial membranes, has since been isolated in two distinct isoforms, known as MCL-1 long (MCL-1L) and MCL-1 short (MCL-1S). MCL-1S has been identified as a pro-apoptotic splice variant of MCL-1L, missing the transmembrane and BH1 and BH2 (Bcl-2 homology) domains. Interaction between these two antagonistic variants can act to regulate cell survival.recognises both the MCL-1L (~38 kDa) and MCL-1S (~30 kDa) isoforms of MCL-1.

WB: 0.5 - 1 µg/ml

Human

A peptide corresponding to 16 amino acids near the centre of human MCL-1.

Rabbit

Polyclonal

IgG

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human Mcl-1 antibody recognizes an epitope within the central region (IN) of human Myeloid cell leukaemia sequence 1 (MCL-1), an anti-apoptotic member of the Bcl-2 family of proteins, first identified in differentiating ML-1 myeloid cells, and expressed in many different cell lines, tissues and a variety of tumours.The MCL-1 protein, localised to intracellular membranes and particularly mitochondrial membranes, has since been isolated in two distinct isoforms, known as MCL-1 long (MCL-1L) and MCL-1 short (MCL-1S). MCL-1S has been identified as a pro-apoptotic splice variant of MCL-1L, missing the transmembrane and BH1 and BH2 (Bcl-2 homology) domains. Interaction between these two antagonistic variants can act to regulate cell survival.Rabbit anti Human Mcl-1 antibody (AHP998) recognizes both the MCL-1L (~38 kDa) and MCL-1S (~30 kDa) isoforms of MCL-1.

Bcl 2 related protein EAT/mcl1, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, BCL2 related, Bcl2-L-3, BCL2L3, EAT, Induced myeloid leukemia cell differentiation protein Mcl 1, Induced myeloid leukemia cell differentiation protein Mcl-1, MCL 1, MCL1-ES, mcl1/EAT, MCL1L, MCL1S, MCL1_HUMAN, MGC104264, MGC1839, Myeloid Cell Leukemia 1, Myeloid cell leukemia ES, Myeloid cell leukemia sequence 1, Myeloid cell leukemia sequence 1 BCL2 related, Myeloid cell leukemia sequence 1 isoform 1, OTTHUMP00000032794, OTTHUMP00000032795, TM