Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] - BSA and Azide free (A253386)

Name: Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] - BSA and Azide free
Brand: Antibodies.com
SKU: A253386
Price: 525.0 USD
Availability: InStock

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$525

Mouse monoclonal [TPSAB1/1961] antibody to Mast Cell Tryptase for IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Delivery

Freight Charges

$40 to United States

Lead Time

4-6 Business Days

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Monospecific Antibody

Specifications

Name

Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] - BSA and Azide free

Description

Mouse monoclonal [TPSAB1/1961] antibody to Mast Cell Tryptase.

Specificity

Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

Applications

IHC-P

Dilutions

IHC-P: 1-2 µg/ml

Reactivity

Human

Immunogen

Recombinant fragment, around amino acids 115-223, of human Tryptase protein. The exact sequence is proprietary.

Host

Mouse

Clonality

Monoclonal

Clone ID

TPSAB1/1961

Isotype

IgG1

Light Chains

kappa

Conjugate

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Molecular Weight

31-36 kDa

Product Form

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Notes

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] (A250206).

Synonyms

alpha II, Lung tryptase, Mast cell alpha II tryptase, Mast cell beta I tryptase, Mast cell protease 7, Mast cell protease II, MCP 7, Pituitary tryptase, Skin tryptase, TPS 1, TPS1, TPS2, TPSAB1, TPSAB1 protein, TPSB1, Tryptase 1, Tryptase alpha 1, tryptase alpha I included, Tryptase alpha II, tryptase alpha II included, tryptase alpha included, tryptase alpha/beta 1, Tryptase beta 1, tryptase beta I included, Tryptase I, tryptase I included, Tryptase III, Tryptase skin

Isotype Controls

Suitable Secondaries

See all Anti-Mouse IgG Secondaries →

Disclaimer

This product is for research use only. It is not intended for diagnostic or therapeutic use.

Scientific Validation Data (3)

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Figure 1: Immunohistochemistry - Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] - BSA and Azide free (A253386)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human tonsil using Anti-Mast Cell Tryptase Antibody [TPSAB1/1961].

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Figure 2: SDS-PAGE - Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] - BSA and Azide free (A253386)

SDS-PAGE analysis of Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 3: Anti-Mast Cell Tryptase Antibody [TPSAB1/1961] - BSA and Azide free (A253386)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Mast Cell Tryptase Antibody [TPSAB1/1961]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

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