Anti-Major Vault Protein Antibody [SPM280] (A250816)

Mouse monoclonal [SPM280] antibody to Major Vault Protein for Flow Cytometry, IF and IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Major Vault Protein Antibody [SPM280]
Description
Mouse monoclonal [SPM280] antibody to Major Vault Protein.
Specificity
This antibody recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Applications
Flow Cytometry, IF, IHC-P
Dilutions
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Proteins precipitated from human breast cancer MCF-7 cells.
Host
Mouse
Clonality
Monoclonal
Clone ID
SPM280
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
104-110 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Major Vault Protein Antibody [SPM280] - BSA and Azide free (A253996).
Synonyms
LRP, Lung resistance related protein, Lung resistance-related protein, Major vault protein, rat, homolog of, MVP, MVP_HUMAN, testicular secretory protein Li 30, VAULT 1, VAULT1
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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