Anti-Macrophage Inflammatory Protein 3 alpha Antibody [J03-4D4] (A280761)

Anti-Macrophage Inflammatory Protein 3 alpha Antibody [J03-4D4]

Mouse monoclonal [J03-4D4] antibody to Macrophage Inflammatory Protein 3 alpha.

This antibody recognises C-C motif chemokine 20, also known as LARC, MIP3A, and SCYA20. The chemokine CCL20 is expressed mostly in the lymphatic tissue, lung, and liver, and is produced by cells involved with the inflammatory and immune responses. CCL20 plays an important role in recruiting inflammatory cells to the site of infection or injury. However, CCL20 is involved with pathogenesis of chronic inflammatory disorders, specifically interstitial lung fibrosis and chronic obstructive pulmonary disease (COPD), and can contribute to tumor metastasis. Inhibition of CCL20, along with its ligand CCR6, might have valuable therapeutic potential for treatment of autoimmune and inflammatory diseases, and is therefore a target of interest for drug discovery. The purified Mouse anti Human CCL20 antibody, clone J03-4D4 (MCA6202GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL20 antibody, clone O03-3H12 (MCA6203B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CCL20 (Ala27-Met96) .

Mouse

Monoclonal

J03-4D4

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CCL20 antibody, clone J03-4D4, recognizes C-C motif chemokine 20, also known as LARC, MIP3A, and SCYA20. The chemokine CCL20 is expressed mostly in the lymphatic tissue, lung, and liver, and is produced by cells involved with the inflammatory and immune responses. CCL20 plays an important role in recruiting inflammatory cells to the site of infection or injury (Soto et al. 2017). However, CCL20 is involved with pathogenesis of chronic inflammatory disorders, specifically interstitial lung fibrosis and chronic obstructive pulmonary disease (COPD), and can contribute to tumor metastasis (Zhang et al. 2017). Inhibition of CCL20, along with its ligand CCR6, might have valuable therapeutic potential for treatment of autoimmune and inflammatory diseases, and is therefore a target of interest for drug discovery (Ranasinghe and Eri 2018). The purified Mouse anti Human CCL20 antibody, clone J03-4D4 (MCA6202GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CCL20 antibody, clone O03-3H12 (MCA6203B) as the detection antibody.

Beta-chemokine exodus-1, C C motif chemokine ligand 20, C-C motif chemokine 20, CC chemokine LARC, Ccl20, CCL20(2-70), CCL20_HUMAN, Chemokine (C C motif) ligand 20, Chemokine CC motif ligand 20, CKb4, Exodus, Exodus 1, LARC, Liver and activation-regulated chemokine, MIP 3 alpha, MIP 3A, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, Small inducible cytokine A20 , Small inducible cytokine subfamily A (Cys Cys) member 20, Small-inducible cytokine A20, ST38