Anti-LY75 Antibody [CD205/3720] (A277697)

Anti-LY75 Antibody [CD205/3720]

Mouse monoclonal [CD205/3720] antibody to LY75.

DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 1,006-1,130, of human LY75 protein. The exact sequence is proprietary.

Mouse

Monoclonal

CD205/3720

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

198 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-LY75 Antibody [CD205/3720] - BSA and Azide free (A278285).

C-type lectin domain family 13 member B, CD 205, CD205, CD205 antigen, CLEC 13B, CLEC13B, DEC 205, DEC-205, DEC205, gp200, gp200 MR6, gp200-MR6, LY 75, Ly-75, LY75_HUMAN, Lymphocyte antigen 75, Renal Cell Carcinoma (gp200)