Anti-LRP1 Antibody [A2Mr alpha-2] (A279602)

Anti-LRP1 Antibody [A2Mr alpha-2]

Mouse monoclonal [A2Mr alpha-2] antibody to LRP1.

This antibody recognises human CD91, also known as Prolow-density lipoprotein receptor-related protein 1, Alpha-2-macroglobulin receptor or apolipoprotein E receptor. CD91 is a 4525 amino acid protein post translationally cleaved into 3 subunits, a 85 kDa type I transmembrane carboxyl chain (LRP85) non-covalently bound to a 515 kDa extracellular N-terminal subunit (LRP515)containing multiple EGF-like and LDL-receptor Class A and Class B domains. Additionally, there is an intracellular domain (LRPICD) which can be cleaved from the transmambrane domain by gamma secretase. Clone A2Mr alpha-2 detects an epitope within the LRP515 chain.CD91 is a multifunctional protein involved in processes inluding the phagocytosis and endocytosis of apoptotic cells , clearance of activated serum alpha-2-macroglobulin , modulation of the inflammatory response and acts as a receptor for Pseudomonas aeruginosa exotoxin A. Mouse anti Human CD91, clone A2Mr alpha-2 has been used extensively for the detection of CD91 by flow cytometry and immunohistochemistry on formalin fixed paraffin embedded tissues.

WB, IP, Flow Cytometry, IHC-Fr, ELISA, IF

ELISA: Direct, Flow Cytometry: 1:50 1:100, WB: Non-reducing conditions, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Human

Purified alpha-2 macroglobulin receptor.

Mouse

Monoclonal

A2Mr alpha-2

IgG1

Unconjugated

Protein A affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human CD91 antibody, clone A2Mr alpha-2 recognizes human CD91, also known as Prolow-density lipoprotein receptor-related protein 1, Alpha-2-macroglobulin receptor or apolipoprotein E receptor. CD91 is a 4525 amino acid protein post translationally cleaved into 3 subunits, a 85 kDa type I transmembrane carboxyl chain (LRP85) non-covalently bound to a 515 kDa extracellular N-terminal subunit (LRP515)containing multiple EGF-like and LDL-receptor Class A and Class B domains. Additionally, there is an intracellular domain (LRPICD) which can be cleaved from the transmambrane domain by gamma secretase (May et al. 2004). Clone A2Mr alpha-2 detects an epitope within the LRP515 chain.CD91 is a multifunctional protein involved in processes inluding the phagocytosis and endocytosis of apoptotic cells (Nilsson et al. 2012), clearance of activated serum alpha-2-macroglobulin (Kristensen et al. 1990), modulation of the inflammatory response (Staudt et al. 2013) and acts as a receptor for Pseudomonas aeruginosa exotoxin A (Kounnas et al. 1992).Mouse anti Human CD91, clone A2Mr alpha-2 has been used extensively for the detection of CD91 by flow cytometry and immunohistochemistry on formalin fixed paraffin embedded tissues (Bourazopoulou et al. 2009).

A2MR, Alpha 2 macroglobulin receptor, alpha 2MR, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor, APR, CD 91, CD91, CD91 antigen, IGFBP3R, LDL receptor related protein 1, Low density lipoprotein receptor related protein 1, Low density lipoprotein related protein 1, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP, LRP 1, LRP 515, LRP 85, LRP ICD, LRP-1, LRP-515, LRP-85, LRP1 protein, LRP1A, LRP1_HUMAN, LRP515, LRP85, LRPICD, MGC88725, Prolow density lipoprotein receptor related protein 1, TbetaR V/LRP 1/IGFBP 3 receptor, TbetaRV/LRP1/IGFBP3 receptor, TGFBR 5, TGFBR5, Type V tgf beta receptor