Anti-Langerin Antibody [LGRN/7356] (A315238)

Anti-Langerin Antibody [LGRN/7356]

Mouse monoclonal [LGRN/7356] antibody to Langerin.

Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.

Human skin.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 50-250) of human Langerin protein. The exact sequence is proprietary.

Mouse

Monoclonal

LGRN/7356

Protein A/G chromatography.

200 µg/ml

48 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

C-type lectin domain family 4 member K, CD207, CLEC4K