Anti-LAMP2 Antibody (A283169)

Anti-LAMP2 Antibody

Rabbit polyclonal antibody to LAMP2.

This antibody recognises CD107b, also known as LAMP-2, a single-pass type I membrane protein belonging to the LAMP family. CD107b is a transmembrane glycoprotein associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. Expression of CD107b varies between cell populations and the molecular weight of CD107b can vary between 92-120 kDa. recognises a band migrating at ~115 kDa in SDS page. CD107b is involved in a range of cellular processes including leukocyte adhesion , protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome along with inter- and intracellular signal transduction (Eskelinen 2006). CD107b has also been implicated in tumor metastasis.

WB, IHC-Fr

IHC-Fr: 10 µg/ml, WB: 1.0 - 2 µg/ml

Human, Mouse

A peptide corresponding to 17 amino acids near the C-terminus of human CD107b.

Rabbit

Polyclonal

IgG

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human CD107b antibody recognizes CD107b, also known as LAMP-2, a single-pass type I membrane protein belonging to the LAMP family. CD107b is a transmembrane glycoprotein associated with lysosomal membranes and is primarily expressed on mononuclear phagocytes. Expression of CD107b varies between cell populations and the molecular weight of CD107b can vary between 92-120 kDa. Rabbit anti Human CD107b antibody recognizes a band migrating at ~115 kDa in SDS page. CD107b is involved in a range of cellular processes including leukocyte adhesion (Kannan et al. 1996), protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome along with inter- and intracellular signal transduction (Eskelinen 2006). CD107b has also been implicated in tumor metastasis (Alessandrini et al. 2017).

CD107 antigen like family member B, CD107 antigen-like family member B, CD107b, LAMP 2, LAMP 2C, LAMP-2, LAMP2_HUMAN, LAMPB, LGP 96, LGP110, LGP96, Lysosomal associated membrane protein 2, Lysosome associated membrane glycoprotein 2, Lysosome associated membrane protein 2, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, MAC3