Anti-Lambda Light Chain Antibody [LcN-2 + ICO-106] (A248996)

Anti-Lambda Light Chain Antibody [LcN-2 + ICO-106]

Mouse monoclonal [LcN-2 + ICO-106] antibody to Lambda Light Chain.

This antibody is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Flow Cytometry, IF, WB

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human

Purified human IgG protein.

Mouse

Oligoclonal

LcN-2 + ICO-106

IgG1, kappa + IgG2a, kappa

Unconjugated

200 µg/ml

~22.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Bence Jones protein, BJP, Constant region of lambda light chains, Ig lambda chain C regions, ig lambda-6 chain C region, IGLC, IGLC 1, IGLC 2, IGLC 3, IGLC1, IGLC2, IGLC3, IGLC6, IGLV, Immunoglobulin lambda constant 1, Immunoglobulin lambda constant regin 1, immunoglobulin lambda gene cluster, Immunoglobulin lambda locus, Immunoglobulin lambda variable cluster, Immunoglobulin: lambda light chain, Mcg marker, Paraprotein