Anti-LAG-3 Antibody [LAG3/7380] (A315231)

$765

Mouse monoclonal [LAG3/7380] antibody to LAG-3 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-LAG-3 Antibody [LAG3/7380]
Description
Mouse monoclonal [LAG3/7380] antibody to LAG-3.
Specificity
LAG-3 (also called CD223) is a high affinity MHC class II ligand present on the surface of CD4+CD8+ T cells and NK cell, with shared homology in structure to CD4 molecules. It has a glutamic acid-proline (EP) repetitive sequence found in other functionally distinct mammalian, parasitic, and bacterial proteins that may influence a conserved biological function. LAG-3+CD4+CD8+ T cells can associate with the T cell receptor (TCR) and downregulate TCR signaling in vitro. LAG-3 inhibits CD4-dependent T cell function via its cytoplasmic domain. LAG-3 Lys-468 within a conserved KIEELE motif is essential for interaction with downstream signaling molecules. Furthermore, as a checkpoint inhibitor target, it may be superior to CTLA-4 and PD-1 since both antibodies only activate effector T-cells, whereas an antagonist LAG-3 antibody can both activate T effector cells (by downregulating the LAG-3 inhibiting signal into pre-activated LAG-3+ cells) and inhibit induced (i.e. antigen-specific) Treg suppressive activity.
Applications
IHC-P
Positive Control
Human tonsil or Hodgkin s lymphoma (IHC-P).
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (around Amino Acids 300-500) of human LAG3 protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
LAG3/7380
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
70 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
CD223, CD223 antigen, FDC protein, Lag3, LAG3_HUMAN, Lymphocyte activating 3, Lymphocyte Activation Gene 3, Lymphocyte activation gene 3 protein, Protein FDC
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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