Anti-KChIP2 Antibody [KCNIP2/7588] (A315207)

Anti-KChIP2 Antibody [KCNIP2/7588]

Mouse monoclonal [KCNIP2/7588] antibody to KChIP2.

In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents control the excitability of neurons and cardiac myocytes. KChIPs are Kv channel-interacting proteins that bind to the cytoplasmic amino termini of Kv4-subunits and are integral components of native Kv4 channel complexes. KChIP family members include KChIP1 expressed in brain, KChIP2 expressed in heart, brain, and lung, and KChIP3 (previously identified as calsenilin) expressed in brain and testis. In rat brain, KChIP1 colocalizes with Kv4.3 in granule cells and KChIP2 colocalizes with Kv4.2 in both neocoritcal and subcortical structures. The KChIPs are members of the recoverin/neuronal calcium sensor-1 subfamily of calcium-binding proteins and show 99% nucleotide homology to DREAM, suggesting that KChIPs may have activity beyond modulation of Kv4 channels.

Human brain.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-270) of human KCNIP2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

KCNIP2/7588

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

27-36 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

A type potassium channel modulatory protein 2, A-type potassium channel modulatory protein 2, Cardiac voltage gated potassium channel modulatory subunit, Cardiac voltage-gated potassium channel modulatory subunit, DKFZp566L1246, KChIP 2, KCIP2_HUMAN, KCNIP 2, Kcnip2, Kv channel interacting protein 2, Kv channel-interacting protein 2, MGC17241, Potassium channel interacting protein 2, Potassium channel-interacting protein 2