Anti-Kappa Light Chain Antibody [KLC709] (CF® 488) (A251135)

This product is discontinued

Anti-Kappa Light Chain Antibody [KLC709] (CF® 488) (A251135) has been discontinued and is no longer available.

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Name
Anti-Kappa Light Chain Antibody [KLC709] (CF® 488)
Description
Mouse monoclonal [KLC709] antibody to Kappa Light Chain (CF® 488).
Specificity
This antibody is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. It recognizes human Ig kappa light chains of both secreted and cell surface immunoglobulin. It detects also free kappa light chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Applications
Flow Cytometry, IHC-P
Dilutions
Flow Cytometry: 1-2 µg/million cells, IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant full-length human IGKC protein.
Host
Mouse
Clonality
Monoclonal
Clone ID
KLC709
Isotype
IgG1
Light Chains
kappa
Conjugate

CF® 488

Excitation: 490nm, Emission: 515nm

Purification
Protein A/G chromatography.
Concentration
100 µg/ml
Molecular Weight
~22.5 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Store at 4-8°C. Antibody is stable for 24 months.
Synonyms
HCAK 1, HCAK1, Ig kappa chain C region, IGKC, IGKCD, Immunoglobulin InV, Immunoglobulin kappa constant, Immunoglobulin kappa constant region, Immunoglobulin kappa light chain, Immunoglobulin kappa light chain constant region, Immunoglobulin KM, Kappa 1 immunoglobulin light chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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