Anti-Kallikrein 5 Antibody [KLK5/4759] (A315200)

$765

Mouse monoclonal [KLK5/4759] antibody to Kallikrein 5 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Kallikrein 5 Antibody [KLK5/4759]
Description
Mouse monoclonal [KLK5/4759] antibody to Kallikrein 5.
Specificity
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin, mammary gland and testis.
Applications
IHC-P
Positive Control
Human skin tissue (IHC). MCF-7 cell lysates.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment of human KLK5 protein (around Amino Acids 1-200). The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
KLK5/4759
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
33 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
HK5, Kallikrein L2, Kallikrein like 2, Kallikrein like protein 2, Kallikrein related peptidase 5, Kallikrein-5, Kallikrein-like protein 2, Kallikrein5, KLK 5, KLK L2, KLK-L2, KLK5, KLK5_HUMAN, KLKL 2, KLKL2, SCTE, Stratum corneum tryptic enzyme, UNQ570/PRO1132
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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