The YY1 transcription factor, also known as NF-E1 (human) and Delta or UCRBP (mouse) is of interest due to its diverse effects on a wide variety of target genes. YY1 is broadly expressed in a wide range of cell types and contains four C-terminal zinc finger motifs of the Cys-Cys-His-His type and an unusual set of structural motifs at its N-terminal end. It binds to downstream elements in several vertebrate ribosomal protein genes, where it apparently acts positively to stimulate transcription and can act either negatively or positively in the context of the immunoglobulin k 3E1 site as well as the P5 promoter of the adenoassociated virus. It thus appears that YY1 is a bifunctional protein, capable of functioning as an activator in some transcriptional control elements and a repressor in others.

Applicazioni

WB, IHC-P

Controllo positivo

Human kidney, tonsil or cervix carcinoma tissues

Diluizioni consigliate

WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Reattività

Human

Immunogeno

His-tagged YY1 protein.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

YY1/5436

Isotipo

IgG2

Catene leggere

kappa

Coniugare

Unconjugated

Purificazione

Protein A/G chromatography.

Concentrazione

200 µg/ml

Peso molecolare

40 kDa / 68 kDa

Forma del prodotto

Liquid

Formulazione

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conservazione

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Sinonimi

CF1, Delta, Delta transcription factor, INO80 complex subunit S, INO80S, NF E1, NF-E1, NFE1, OTTHUMP00000197459, Transcriptional repressor protein YY1, TYY1_HUMAN, UCR motif DNA binding protein, UCRBP, Yin and yang 1, Yin and Yang 1 protein, Yin Yang 1, Ying Yang 1, YY 1, YY 1 transcription factor, YY-1, YY1 transcription factor

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.