Ricombinante Anti-Von Willebrand Factor Anticorpo [VWF/4384R] (A278077)

Anti-Von Willebrand Factor Antibody [VWF/4384R]

Recombinant rabbit monoclonal [VWF/4384R] antibody to Von Willebrand Factor.

Human von Willebrand factor (VWF or factor VIII-related antigen) is a 309 kDa multimeric plasma glycoprotein, important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Von Willebrand factor also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Von Willebrand factor is synthesized by endothelial cells and is reported to be expressed in a number of tumors of vascular origin. IHC results aid in the classification of acute myeloid leukemia FAB type M7, angiosarcoma and epithelioid hemangioendothelioma.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 1150-1250, of human Von Willebrand Factor protein. The exact sequence is proprietary.

Rabbit

Monoclonal

VWF/4384R

IgG

Protein A/G chromatography.

200 µg/ml

250 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Von Willebrand Factor Antibody [VWF/4384R] - BSA and Azide free (A278665).

Coagulation factor VIII , Coagulation factor VIII VWF, F8VWF, Factor VIII related antigen, von Willebrand antigen 2, von Willebrand antigen II, Von Willebrand disease, VWD, vWF, VWF_HUMAN