Note generali
Mouse anti Human vWF antibody, clone E01-1C8, recognizes von Willebrand factor (vWF) a multifunctional glycoprotein that plays essential roles in primary and secondary homeostasis, mediates platelet adhesion and is a carrier of coagulation factor VIII (Yasar et al. 2018). vWF is present in blood plasma, the subendothelial matrix, platelet granules (a granules) and endothelial cells (Kawecki et al. 2017). In endothelial cells, the vWF is stored in mature Weibel-Palade bodies before it is secreted into the plasma (Yasar et al. 2018). vWF plasma levels are influenced by genetic, pathological, hormonal and environmental interactions (Swystun & Lillicrap 2018). Upon vascular injury, vWF mediates the anchoring of platelets to the subendothelium leading to the formation of a platelet plug and the arrest of bleeding. Due to its acute release by the activated epithelium, vWF has been considered a marker of inflammation in various pathologies. However there is evidence that vWF is able to play a direct role in inflammation by recruiting leukokcytes to sites of inflammation (Kawecki et al. 2017). The biotinylated Mouse anti Human vWF antibody, clone E01-1C8 (MCA6289B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human vWF antibody, clone C01-1F2 (MCA6288GA) as the capture antibody.
