This antibody recognises human TSLP (thymic stromal lymphopoietin), a 132 amino acid secreted haemopoietic cytokine which shares biological properties with interleukin-7 (IL-7), including involvement in B-cell development, and the activation and phosphorylation of STAT3 and STAT5.TSLP is expressed in the heart, liver and prostate and functions through binding to a receptor complex consisting of the TSLPR (thymic stromal lymphopoietin receptor) and the IL-7R alpha chain. Properties attributed to TSLP include the induction of monocytes to release T cell-attracting chemokines, enhancing the maturation of CD11c+ dendritic cells and their ability to stimulate T cells, and strong evidence suggests that TSLP plays a pivotal role in allergic immune responses.

Applicazioni

WB, ELISA, IHC-P

Diluizioni consigliate

ELISA: 0.5 - 2 µg/ml, WB: 0.1 - 0.2 µg/ml

Reattività

Human

Immunogeno

Recombinant human TSLP.

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

1 mg/ml after reconstitution.

Forma del prodotto

Lyophilized

Ricostituzione

Reconstitute with 0.1 ml of distilled water. For long term storage the addition of 0.09% sodium azide is recommended.

Formulazione

Supplied in Phosphate Buffered Saline.

Conservazione

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Note generali

Rabbit anti Human TSLP antibody recognizes human TSLP (thymic stromal lymphopoietin), a 132 amino acid secreted haemopoietic cytokine which shares biological properties with interleukin-7 (IL-7), including involvement in B-cell development, and the activation and phosphorylation of STAT3 and STAT5.TSLP is expressed in the heart, liver and prostate and functions through binding to a receptor complex consisting of the TSLPR (thymic stromal lymphopoietin receptor) and the IL-7R alpha chain. Properties attributed to TSLP include the induction of monocytes to release T cell-attracting chemokines, enhancing the maturation of CD11c+ dendritic cells and their ability to stimulate T cells, and strong evidence suggests that TSLP plays a pivotal role in allergic immune responses.

Sinonimi

Thymic stromal lymphopoietin, Thymic stromal lymphopoietin protein TSLP, TSLP protein, TSLP_HUMAN

Controlli isotipo

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Prodotti alternativi a Anti-TSLP Anticorpo (A283092)

(5)

A323777