This antibody recognises human CD289, otherwise known as toll receptor 9, a member of the evolutionarily conserved toll-like receptor family (TLRs), which play an important role in the recognition of invading microbial pathogens during innate immunity.CD289 is expressed preferentially by the spleen, lymph node, bone marrow and peripheral blood leucocytes and recognises viral DNA and unmethylated CpG sequences in bacterial DNA. Unlike other TLRs, TLR9 is dependant upon the adaptor molecule MyD88 for signaling activation.Rabbit anti Human CD289 antibody has been shown as suitable for use in IHC on human Jurkat cell cytospins @ 2ug/ml.

Applicazioni

WB, IHC-Fr

Diluizioni consigliate

WB: 0.5 - 1 µg/ml

Reattività

Human, Mouse, Rat

Immunogeno

Synthetic peptide corresponding to 15 amino acids near the centre of human CD289.

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

1 mg/ml

Peso molecolare

Approximately 95 kDa in human Jurkat cell lysates . (Predicted Mwt. 115-120 kDa).

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Rabbit anti Human CD289 antibody recognizes human CD289, otherwise known as toll receptor 9, a member of the evolutionarily conserved toll-like receptor family (TLRs), which play an important role in the recognition of invading microbial pathogens during innate immunity.CD289 is expressed preferentially by the spleen, lymph node, bone marrow and peripheral blood leucocytes and recognizes viral DNA and unmethylated CpG sequences in bacterial DNA. Unlike other TLRs, TLR9 is dependant upon the adaptor molecule MyD88 for signaling activation.Rabbit anti Human CD289 antibody has been shown as suitable for use in IHC on human Jurkat cell cytospins @ 2ug/ml.

Sinonimi

CD 289, CD289, TLR 9, TLR9_HUMAN, Toll like receptor 9, Toll like receptor 9 isoform A precursor, Toll like receptor 9 isoform B, Toll-like receptor 9

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.