This antibody recognises human CD286, also known as Toll-like receptor 6 (TLR6), a member of the evolutionarily conserved toll-like receptor family (TLRs) and close homologue of CD281 (TLR1), that is expressed by monocytes, CD11c+ immature dendritic cells and endothelial cells of skin microvessels.TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD286 acts via a cytokine signaling pathway to induce the activation of NF-kappaB, through the formation of dimers with CD282 (TLR2) which coordinate macrophage activation by Gram-positive bacteria and zymosan. CD286/CD282 dimers are also involved in apoptotic responses through recognition of mycoplasmal lipoproteins.Rabbit anti Human CD286 antibody does not recognize CD281 (TLR1). Rabbit anti Human CD286 antibody has been shown as suitable for use in IHC on Jurkat cell cytospins at 2ug/ml.

Applicazioni

WB, IHC-Fr

Diluizioni consigliate

WB: 0.5 - 1 µg/ml

Reattività

Human

Immunogeno

Synthetic peptide corresponding to 13 amino acids near the centre of human CD286.

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

1 mg/ml

Peso molecolare

Approximately 98 kDa and 110 kDa in human Jurkat cell lysates (predicted Mwt. 91.9 kDa). Doublet band may be due to protein modification or the recognition of two different isoforms by the same gene.

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Rabbit anti Human CD286 antibody recognizes human CD286, also known as Toll-like receptor 6 (TLR6), a member of the evolutionarily conserved toll-like receptor family (TLRs) and close homologue of CD281 (TLR1), that is expressed by monocytes, CD11c+ immature dendritic cells and endothelial cells of skin microvessels.TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD286 acts via a cytokine signaling pathway to induce the activation of NF-kappaB, through the formation of dimers with CD282 (TLR2) which coordinate macrophage activation by Gram-positive bacteria and zymosan. CD286/CD282 dimers are also involved in apoptotic responses through recognition of mycoplasmal lipoproteins.Rabbit anti Human CD286 antibody does not recognize CD281 (TLR1). Rabbit anti Human CD286 antibody has been shown as suitable for use in IHC on Jurkat cell cytospins at 2ug/ml.

Sinonimi

CD286, CD286 antigen, TLR 6, TLR6_HUMAN, Toll like receptor 6 precursor, Toll-like receptor 6

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.