Anti-TLR4 Anticorpo [TLR4/230] (A253332)

Anti-TLR4 Antibody [TLR4/230] - BSA and Azide free

Mouse monoclonal [TLR4/230] antibody to TLR4.

This antibody reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Functional Studies

Human, Monkey, Porcine, Canine, Rat, Guinea Pig

Recombinant full-length human TLR4 protein.

Mouse

Monoclonal

TLR4/230

IgG2a

kappa

Protein A/G chromatography.

1 mg/ml

95-120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-TLR4 Antibody [TLR4/230] (A250152).

ARMD10, CD284, CD284 antigen, Homolog of Drosophila toll, hToll, TLR 4, TLR4_HUMAN, TOLL, Toll like receptor 4, Toll-like receptor 4