Anti-TLR4 Anticorpo [TLR4/230] (A250152)

Anti-TLR4 Antibody [TLR4/230]

Mouse monoclonal [TLR4/230] antibody to TLR4.

This antibody reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Functional Studies

Human, Monkey, Porcine, Canine, Rat, Guinea Pig

Recombinant full-length human TLR4 protein.

Mouse

Monoclonal

TLR4/230

IgG2a

kappa

Protein A/G chromatography.

200 µg/ml

95-120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-TLR4 Antibody [TLR4/230] - BSA and Azide free (A253332).

ARMD10, CD284, CD284 antigen, Homolog of Drosophila toll, hToll, TLR 4, TLR4_HUMAN, TOLL, Toll like receptor 4, Toll-like receptor 4