This antibody recognises human CD283, otherwise known as toll receptor 3, a 103.8 kDa member of the evolutionarily conserved toll-like receptor family (TLRs), expressed at high levels in the placenta and pancreas and also expressed by dendritic cells.TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD283 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and type I interferons, and has been shown to recognize double-stranded viral RNA, including that of the Influenza A and West Nile virus.Rabbit anti Human CD283 antibody has been shown as suitable for use in IHC on EL4 cytospins at 1ug/ml.

Applicazioni

WB, IHC-Fr

Diluizioni consigliate

WB: 1.0 - 2 µg/ml

Reattività

Human, Mouse

Immunogeno

Synthetic peptide corresponding to 15 amino acids near the C-terminus of human CD283.

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

1 mg/ml

Peso molecolare

Approximately 103.8 kDa in human Daudi cell lysates.

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Rabbit anti Human CD283 antibody recognizes human CD283, otherwise known as toll receptor 3, a 103.8 kDa member of the evolutionarily conserved toll-like receptor family (TLRs), expressed at high levels in the placenta and pancreas and also expressed by dendritic cells.TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD283 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and type I interferons, and has been shown to recognize double-stranded viral RNA, including that of the Influenza A and West Nile virus.Rabbit anti Human CD283 antibody has been shown as suitable for use in IHC on EL4 cytospins at 1ug/ml.

Sinonimi

CD283, CD283 antigen, IIAE2, TLR 3, TLR3/CD283, TLR3_HUMAN, Toll Like Receptor 3, Toll-like receptor 3

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.