Ricombinante Anti-TL1A Anticorpo [VEGI/7799R] (A315734)

Anti-TL1A Antibody [VEGI/7799R]

Recombinant rabbit monoclonal [VEGI/7799R] antibody to TL1A.

VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.

IHC-P

Endothelial cells. Colon, intestine, placenta, lung or prostate.

IHC: 1-2 µg/ml

Human

Recombinant full-length human VEGI protein.

Rabbit

Monoclonal

VEGI/7799R

IgG

Unconjugated

Protein A chromatography.

200 µg/ml

22 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

MGC129934, MGC129935, tl1, TL1 A, tnf ligand related molecule 1, TNF ligand-related molecule 1, tnf superfamily ligand tl1a, TNF15_HUMAN, TNFSF15, Tumor necrosis factor (ligand) superfamily member 15, Tumor necrosis factor ligand superfamily member 15, Tumor necrosis factor ligand superfamily member 15, secreted form, Vascular endothelial cell growth inhibitor, Vascular endothelial growth inhibitor, Vascular endothelial growth inhibitor 192a, vegi, VEGI192A