Ricombinante Anti-Thymidine Phosphorylase Anticorpo [TYMP/2890R] (A251567)

Anticorpo monoclonale [TYMP/2890R] di coniglio contro Thymidine Phosphorylase per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-Thymidine Phosphorylase Antibody [TYMP/2890R] - BSA and Azide free
Descrizione
Recombinant rabbit monoclonal [TYMP/2890R] antibody to Thymidine Phosphorylase.
Specificità
This antibody recognizes a protein (amino acid 482) of 55kDa (in vivo 110kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
Applicazioni
IHC-P
Diluizioni consigliate
IHC-P: 1-2 µg/ml
Reattività
Human, Mouse, Rat
Immunogeno
Recombinant full-length human Thymidine Phosphorylase protein.
Specie ospite
Rabbit
Clonalità
Monoclonal
Clona ID
TYMP/2890R
Isotipo
IgG
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
55 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Thymidine Phosphorylase Antibody [TYMP/2890R] (A248385).
Sinonimi
ECGF, ECGF 1, ECGF1, Endothelial cell growth factor 1, Endothelial cell growth factor 1 platelet derived, Endothelial cell growth factor, platelet-derived, Gliostatin, hPD ECGF, MEDPS1, MNGIE, MTDPS1, PD ECGF, PD-ECGF, PDECGF, PDEGF, Platelet derived endothelial cell growth factor, Platelet derived endothelial growth factor, Platelet-derived endothelial cell growth factor, TdRPase, TP, Tymp, TYPH_HUMAN
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Prodotti alternativi a Anti-Thymidine Phosphorylase Anticorpo [TYMP/2890R] (A251567)

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