Mouse monoclonal [TGFB2/1679] antibody to TGF beta 3.
Specificità
Transforming growth factor bs (TGFbs) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFa. It is now realized that TGFbs mediate many cell-cell interactions that occur during embryonic development. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80% identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.
Applicazioni
IHC-P
Controllo positivo
Prostate or lung carcinoma.
Diluizioni consigliate
IHC: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant full-length human TGFB2 protein.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
TGFB2/1679
Isotipo
IgG1
Catene leggere
kappa
Coniugare
Unconjugated
Purificazione
Protein A/G chromatography.
Concentrazione
200 µg/ml
Peso molecolare
13 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
![SDS-PAGE - Anti-TGF beta 3 Antibody [Research Grade Biosimilar] - Low endotoxin, Azide free (A324257) - Antibodies.com](https://cdn.antibodies.com/image/catalog/324/A324257_1.jpg?profile=product_alternative)
