Anti-TDP43 Anticorpo [TARDP/349] (A315714)

$765

Anticorpo monoclonale [TARDP/349] di topo contro TDP43 per ELISA, WB e IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com

Prodotti consigliati per Anti-TDP43 Anticorpo

Nome
Anti-TDP43 Antibody [TARDP/349]
Descrizione
Mouse monoclonal [TARDP/349] antibody to TDP43.
Specificità
TARDBP (TAR DNA binding protein), also known as TDP-43, is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta, lung, pancreas, spleen and genital tract, TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition, TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events, various isoforms exist for TARDBP.
Applicazioni
ELISA, WB, IHC-P
Controllo positivo
Human cerebrum or colon.
Diluizioni consigliate
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment within human TDP43 aa 200 to the C-terminus.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
TARDP/349
Isotipo
IgG1
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
200 µg/ml
Peso molecolare
44 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sinonimi
ALS10, OTTHUMP00000002171, OTTHUMP00000002172, OTTHUMP00000002173, TADBP_HUMAN, TAR DNA binding protein, TAR DNA binding protein 43, TAR DNA-binding protein 43, TARDBP, TDP 43, TDP-43
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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