Anti-Superoxide Dismutase 1 Anticorpo [SOD1/4593] (A315696)

Anti-Superoxide Dismutase 1 Antibody [SOD1/4593]

Mouse monoclonal [SOD1/4593] antibody to Superoxide Dismutase 1.

Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

IHC-P

HeLa or Jurkat cells. Human breast or ovarian carcinoma

IHC: 1-2 µg/ml

Human

Recombinant full-length human SOD1 protein.

Mouse

Monoclonal

SOD1/4593

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

16 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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