Anti-SREBP2 Anticorpo [SREBP2/1580] (A278401)

Anti-SREBP2 Antibody [SREBP2/1580] - BSA and Azide free

Mouse monoclonal [SREBP2/1580] antibody to SREBP2.

The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.

ELISA, IF, WB, IHC-P

IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human

Recombinant full-length human SREBP2 protein.

Mouse

Monoclonal

SREBP2/1580

IgG1

kappa

Protein A/G chromatography.

1 mg/ml

68 kDa / 125 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-SREBP2 Antibody [SREBP2/1580] (A277813).

AI608257, bHLHd2, Class D basic helix-loop-helix protein 2, OTTHUMP00000028740, Processed sterol regulatory element-binding protein 2, SRBP2_HUMAN, SREBF 2, Srebf2, SREBF2 protein, SREBP 2, SREBP-2, SREBP2gc, sterol regulatory element binding factor 2, Sterol regulatory element binding protein 2, Sterol regulatory element binding transcription factor 2, Sterol regulatory element-binding transcription factor 2