Anti-SOS1 Anticorpo [SOS-01] (A281774)

Anti-SOS1 Antibody [SOS-01]

Mouse monoclonal [SOS-01] antibody to SOS1.

This antibody recognises SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150 kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 , and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.

WB, ELISA, IF

WB: 1 µg/ml

Human, Mouse

Synthetic peptide sequence THPSMHRDGPPLLENAHSS of human SOS1.

THPSMHRDGPPLLENAHSS

Mouse

Monoclonal

SOS-01

IgG1

Unconjugated

1 mg/ml

Approximately 150 kDa in K562 and RAJI human cell lysates under reducing conditions.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human SOS1 antibody, clone SOS-01 recognizes SOS1 (son of sevenless homolog 1), a ubiquitously expressed 1333 amino acid ~150 kDa intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases.Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (Hart et al. 2002), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features (Hanna et al. 2009).

alternate SOS1, GF1, GGF1, GINGF, gingival fibromatosis, gingival fibromatosis hereditary 1, Guanine nucleotide exchange factor, HGF, NS4, Son of sevenless homolog 1, Son of sevenless homolog 1 (Drosophila), SOS Ras/Rac guanine nucleotide exchange factor 1, SOS-1, SOS1_HUMAN