This antibody recognises epitopes within the C-terminal region of sodium-dependent myo-inositol cotransporter-1 (SLC5A3), also known as SMIT-1. SLC5A3 is a~80 kDa membrane associated transporter which is expressed in many human tissues including the brain, kidney and placenta. It is up-regulated in hypertonic conditions and functions in cellular osmoregulation by regulating myo-inositol (MI) uptake. MI is the precursor for phosphatidylinositol and its derivatives, all of which have functions in signal transduction.Up-regulation of SLC5A3 may be associated with an increased risk for bipolar I disorder, and is also thought to be a factor in the pathophysiology of Down syndrome.

Applicazioni

IHC-P

Diluizioni consigliate

IHC-P 1: 10 - 30 µg/ml

Reattività

Human

Immunogeno

Synthetic peptide corresponding to the C-terminus of human SLC5A3, conjugated to Keyhole Limpet Haemocyanin.

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

1 mg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Rabbit anti Human SLC5A3 antibody detects epitopes within the C-terminal region of sodium-dependent myo-inositol cotransporter-1 (SLC5A3), also known as SMIT-1. SLC5A3 is a~80 kDa membrane associated transporter which is expressed in many human tissues including the brain, kidney and placenta. It is up-regulated in hypertonic conditions and functions in cellular osmoregulation by regulating myo-inositol (MI) uptake. MI is the precursor for phosphatidylinositol and its derivatives, all of which have functions in signal transduction.Up-regulation of SLC5A3 may be associated with an increased risk for bipolar I disorder, and is also thought to be a factor in the pathophysiology of Down syndrome.

Sinonimi

Na(+)/myo inositol cotransporter, Na(+)/myo-inositol cotransporter, SC5A3_HUMAN, SMIT, SMIT2, Sodium/myo inositol cotransporter, sodium/myo inositol cotransporter 1, Sodium/myo-inositol cotransporter, solute carrier family 5 (inositol transporters), member 3, Solute carrier family 5 member 3

Controlli isotipo

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.