Anti-SLAM / CD150 Anticorpo [SLAM.4] (A281743)

$375

Anticorpo monoclonale [SLAM.4] di topo contro SLAM / CD150 per Flow Cytometry, IP e ICC.

Alternative Formats and ConjugatesAlternative Formats

PE
Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-SLAM / CD150 Antibody [SLAM.4] - BSA and Azide free
Descrizione
Mouse monoclonal [SLAM.4] antibody to SLAM / CD150.
Specificità
This antibody recognises CD150 also known as signaling lymphocyte activation molecule (SLAM), is a member of the immunoglobulin superfamily. CD150 is expressed in dendritic cells, Natural Killer (NK) cells, B and T cells. CD150 is a membrane phosphoglycoprotein which contains 2 extracellular domains corresponding to a variable and constant region, a general feature of the Ig superfamily. CD150 also has a cytoplasmic domain which contains 3 unique tyrosine motifs with a conserved TxYxxV sequence. This tyrosine motif is the binding domain for SLAM-associated protein (SAP) which form a complex together (Sayos et al 1998, Poy et al. 1999). This complex plays a role in the regulation of Natural killer (NK) and T cell development. Mutations to SAP in humans results in X-linked lymphoproliferative disease which is a fatal immunological disorder. Activation of CD150 co-activates T- or B-lymphocytes responses and plays a role in bidirectional T-B cell stimulation. It can also regulate NK and T cell development, B cell regulation and antibody production/isotype switching (Veillette 2006). CD150 is also the receptor that the measles virus recognises. The SLAM.4 clone has been used in flow cytometry to analyze the cell distribution of CD150 on leucocytes and lymphocytes as well as to distinguish between subsets of CD4+ and CD8+ T lymphocytes.
Applicazioni
Flow Cytometry, IP, ICC
Reattività
Human
Immunogeno
Human CD150-transfected 300.19 cells.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
SLAM.4
Isotipo
IgG1
Coniugare

Unconjugated

Purificazione
Protein A affinity chromatography of tissue culture supernatant and 0.2µM filter sterilized.
Concentrazione
1 mg/ml
Purezza
>95% (by SDS-PAGE).
Forma del prodotto
Liquid
Formulazione
Supplied in Phosphate Buffered Saline.
Conservazione
Store undiluted at 4°C. Do not freeze!
Note generali
Mouse anti Human CD150 antibody, clone SLAM.4 recognizes CD150 also known as signaling lymphocyte activation molecule (SLAM), is a member of the immunoglobulin superfamily. CD150 is expressed in dendritic cells, Natural Killer (NK) cells, B and T cells (Bhattocharjee and Yadava 2018). CD150 is a membrane phosphoglycoprotein which contains 2 extracellular domains corresponding to a variable and constant region, a general feature of the Ig superfamily (Cocks et al. 1995). CD150 also has a cytoplasmic domain which contains 3 unique tyrosine motifs with a conserved TxYxxV sequence. This tyrosine motif is the binding domain for SLAM-associated protein (SAP) which form a complex together (Sayos et al 1998, Poy et al. 1999). This complex plays a role in the regulation of Natural killer (NK) and T cell development. Mutations to SAP in humans results in X-linked lymphoproliferative disease which is a fatal immunological disorder (Coffey et al. 1998). Activation of CD150 co-activates T- or B-lymphocytes responses and plays a role in bidirectional T-B cell stimulation (Carballido et al. 1997). It can also regulate NK and T cell development, B cell regulation and antibody production/isotype switching (Veillette 2006). CD150 is also the receptor that the measles virus recognizes (Tatsuo et al. 2000). The SLAM.4 clone has been used in flow cytometry to analyze the cell distribution of CD150 on leucocytes and lymphocytes as well as to distinguish between subsets of CD4+ and CD8+ T lymphocytes (Romero et al. 2001).
Sinonimi
4933415F16, AA177906, CD 150, CD150, CD150 antigen, CDw150, Estm51, Ipo 3, IPO-3, Ipo3, MGC151472, MGC151476, OTTHUMP00000025670, OTTHUMP00000060252, RGD1560634, Signaling lymphocytic activation molecule, Signaling lymphocytic activation molecule family member 1, Signaling lymphocytic activation molecule family member 1, isoform CRA_a, Signaling lymphocytic activation molecule family member 1, isoform CRA_b, Signaling lymphocytic activation molecule precursor, Slaf1, SLAF1_HUMAN, SLAM family, member 1, Slamf 1, SLAMF1, SLAMF1 protein
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Prodotti alternativi a Anti-SLAM / CD150 Anticorpo [SLAM.4] (A281743)

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