Anti-SHP1 Anticorpo [PTPN6/7544] (A315638)

Anti-SHP1 Antibody [PTPN6/7544]

Mouse monoclonal [PTPN6/7544] antibody to SHP1.

PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).

IHC-P

Human tonsil, lymph node or spleen.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 395-595) of human PTPN6 protein. The exact sequence is proprietary.

Mouse

Monoclonal

PTPN6/7544

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

65 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

70Z-SHP, EC 3.1.3.48, HCP, HCPH, Hematopoietic cell phosphatase, Hematopoietic cell protein tyrosine phosphatase, Hematopoietic cell protein-tyrosine phosphatase, HPTP1C, Protein tyrosine phosphatase 1C, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase SHP1, Protein-tyrosine phosphatase 1C, protein-tyrosine phosphatase SHP 1, Protein-tyrosine phosphatase SHP-1, PTN6_HUMAN, PTP 1C, PTP-1C, PTP1C, Ptpn6, SH PTP 1, SH PTP1, SH-PTP1, SHP 1, SHP 1L, SHP1L, tyrosine protein phosphatase non receptor type 6, Tyrosine-protein phosphatase non-receptor type 6