Anti-SDF1 alpha Anticorpo (A283936)

Anti-SDF1 alpha Antibody - BSA and Azide free

Rabbit polyclonal antibody to SDF1 alpha.

This antibody recognises human SDF-1 alpha, otherwise known as CXCL12a, a 68 amino acid stromal cell derived CXC chemokine, which arises from alternative splicing of the SDF-1 gene. The two isoforms, SDF-1 alpha and SDF-1 beta, share an identical amino acid sequence, except for an additional four residues in the C-terminal region of the beta isoform.SDF-1 binds with high-affinity to the G protein–coupled receptor CXCR4 (fusin) and acts as a chemoattractant for T and B lymphocytes, monocytes and migratory neurons, and is a vital factor in haematopoiesis and angiogenesis. By competitively binding to CXCR4, SDF-1 acts as an inhibitor for the CXCR4-mediated entry of HIV-1 virus into target T-cells, and the SDF-1-CXCR4 interaction is important for the regulation of trafficking of normal and malignant stem cells.

WB, ELISA, IHC-P, Functional Assays

ELISA: 0.5 - 2 µg/ml, Functional Assays: 2.0 - 4.0 µg/ml, IHC-P: 0.5 µg/ml, WB: 0.1 - 0.2 µg/ml

Human

Recombinant human SDF-1 alpha.

Rabbit

Polyclonal

IgG

Unconjugated

1 mg/ml after reconstitution.

Reconstitute with 0.1 ml of distilled water. For long term storage the addition of 0.09% sodium azide is recommended. For functional studies do not add sodium azide.

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti Human SDF-1 alpha antibody recognizes human SDF-1 alpha, otherwise known as CXCL12a, a 68 amino acid stromal cell derived CXC chemokine, which arises from alternative splicing of the SDF-1 gene. The two isoforms, SDF-1 alpha and SDF-1 beta, share an identical amino acid sequence, except for an additional four residues in the C-Terminal region of the beta isoform.SDF-1 binds with high-affinity to the G protein–coupled receptor CXCR4 (fusin) and acts as a chemoattractant for T and B lymphocytes, monocytes and migratory neurons, and is a vital factor in haematopoiesis and angiogenesis. By competitively binding to CXCR4, SDF-1 acts as an inhibitor for the CXCR4-mediated entry of HIV-1 virus into target T-cells, and the SDF-1-CXCR4 interaction is important for the regulation of trafficking of normal and malignant stem cells.

C-X-C motif chemokine 12, Chemokine (C X C motif) ligand 12 , Chemokine (C-X-C motif) ligand 12, CXCL12, hIRH, hSDF-1, Intercrine reduced in hepatomas, IRH, PBSF, Pre B cell growth stimulating factor, Pre-B cell growth-stimulating factor, SCYB12, SDF 1 , SDF 1 alpha, SDF 1 beta , SDF 1b , SDF-1, SDF-1-alpha(3-67), SDF1, SDF1 alpha (3-67), SDF1 beta (3-72), SDF1A, SDF1B, SDF1_HUMAN, Stromal cell derived factor 1, TLSF, TLSF a , TLSF b, TLSFa, TLSFb, TPAR1