NF-κB Pathway
Nuclear factor kappa beta (NF-kB) is a nearly ubiquitous pathway responsible for mediating DNA transcription, and thereby cell function. The pathway is activated by a variety of stimuli, including cellular stress, cytokines, free radicals, UV radiation, oxidized LDL, and bacterial/viral infection.
Activated NF-kB translocates to the nucleus, where it binds to specific sequences of DNA called response elements. This DNA/NF-kB complex then recruits RNA polymerase and other coactivators, which transcribe downstream DNA into mRNA for protein synthesis.
Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.
Related Products
| Target | Antibody | Reactivity | Applications |
| AKT | Rabbit pAb to AKT | Human, Mouse, Rat | WB, IHC | AKT (Phospho Ser473) | Rabbit pAb to AKT (pSer473) | Human, Mouse, Rat | WB, IHC | CHUK | Rabbit pAb to CHUCK | Human, Mouse | WB, IHC, ICC/IF |
| CHUK | Goat pAb to CHUK | Human | ELISA, WB | HDAC1 | Goat pAb to HDAC1 | Human, Mouse | ELISA, WB, ChIP | HDAC5 | Rabbit pAb to HDAC5 | Human, Mouse, Rat | WB, IHC, IF | HDAC7 | Rabbit pAb to HDAC7 | Human, Mouse, Rat | WB, IHC, IF | NFKB1 | Rabbit pAb to NFKB1 | Human, Mouse, Rat | WB, IHC, IF | NFKB1 (Phospho Ser337) | Rabbit pAb to NFKB1 (pSer337) | Human, Mouse, Rat | WB, IHC, IF | NFKB1 (Phospho Ser893) | Rabbit pAb to NFKB1 (pSer893) | Human | IHC, IF | NFKB1 (Phospho Ser907) | Rabbit pAb to NFKB1 (pSer907) | Human | WB, IHC | NFKB1 (Phospho Ser927) | Rabbit pAb to NFKB1 (pSer927) | Human, Mouse, Rat | WB, IHC, IF | NFKB1 (Phospho Ser932) | Rabbit pAb to NFKB1 (pSer932) | Human, Mouse, Rat | WB, IHC | NFKB2 | Rabbit pAb to NFKB2 | Human, Mouse, Rat | WB, IHC | NF-κB p65 | Rabbit pAb to NF-κB p65 | Human, Mouse, Rat | WB, IHC | NF-κB p65 (Phospho Thr254) | Rabbit pAb to NF-κB p65 (pThr254) | Human, Mouse, Rat | WB, IHC, IF | NF-κB p65 (Phospho Ser276) | Rabbit pAb to NF-κB p65 (pSer276) | Human, Mouse, Rat | WB, IHC, IF | NF-κB p65 (Phospho Thr435) | Rabbit pAb to NF-κB p65 (pThr435) | Human, Mouse, Rat | WB, IHC, IF | NF-κB p65 (Phospho Ser529) | Rabbit pAb to NF-κB p65 (pSer529) | Human | WB, IHC, IF | NF-κB p65 (Phospho Ser468) | Rabbit pAb to NF-κB p65 (pSer468) | Human, Mouse, Rat | WB, IHC, IP | NF-κB p65 (Phospho Ser536) | Rabbit pAb to NF-κB p65 (pSer536) | Human, Mouse, Rat | WB, IHC, IF | RELA | Rabbit pAb to RELA | Human, Mouse, Rat | WB, IHC, IF |