Ricombinante Anti-RBP4 Anticorpo [RBP4/8090R] (A315543)

Anti-RBP4 Antibody [RBP4/8090R]

Recombinant rabbit monoclonal [RBP4/8090R] antibody to RBP4.

Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

IHC-P

HeP-G2 cells. Human kidney, pancreas or liver tissues.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 29-148) of human RBP4 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

RBP4/8090R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

25 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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