Serum Amyloid A è un gene codificato dal simbolo SAA1. È noto anche come: Serum amyloid A-1 protein; SAA; SAA1. Serum Amyloid A ha una massa di 13.53kDa e una lunghezza di amminoacidi di 122.
Offriamo 7 proteine Serum Amyloid A
Informazioni su geni e proteine
Riepilogo UniProt
Major acute phase protein.
Sommario di Entrez
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
Specificità del tessuto
Expressed by the liver; secreted in plasma (at protein level).
Somiglianze di sequenza
Belongs to the SAA family.
Modifica post-translazionale
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
Posizione cellulare
Secreted.
