PF4 è un gene codificato dal simbolo PF4. Comunemente indicato anche come: Platelet factor 4; PF-4; C-X-C motif chemokine 4; Iroplact; Oncostatin-A; CXCL4; SCYB4. PF4 ha una massa di 10.85kDa e una lunghezza di amminoacidi di 101.
Offriamo 8 proteine PF4
Informazioni su geni e proteine
Riepilogo UniProt
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.
Sommario di Entrez
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum.
Somiglianze di sequenza
Belongs to the intercrine alpha (chemokine CxC) family.
Posizione cellulare
Secreted.
