Osteopontin è un gene codificato dal simbolo SPP1. Comunemente indicato anche come: Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1; SPP-1; Urinary stone protein; Uropontin; SPP1; BNSP; OPN. Osteopontin ha una massa di 35.42kDa e una lunghezza di amminoacidi di 314.
Offriamo 5 proteine Osteopontin
Informazioni su geni e proteine
Riepilogo UniProt
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Sommario di Entrez
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Bone. Found in plasma.
Somiglianze di sequenza
Belongs to the osteopontin family.
Modifica post-translazionale
Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif.
Posizione cellulare
Secreted.
