LIF è un gene codificato dal simbolo LIF. Comunemente indicato anche come: Leukemia inhibitory factor; Differentiation-stimulating factor; D factor; Melanoma-derived LPL inhibitor; MLPLI; HILDA. LIF ha una massa di 22.01kDa e una lunghezza di amminoacidi di 202.
Offriamo 8 proteine LIF
Informazioni su geni e proteine
Riepilogo UniProt
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Sommario di Entrez
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Somiglianze di sequenza
Belongs to the LIF/OSM family.
Posizione cellulare
Secreted.
