Interferon gamma è un gene codificato dal simbolo IFNG. Comunemente indicato anche come: IFN-gamma; Immune interferon; IFNG. Interferon gamma ha una massa di 19.35kDa, una lunghezza di amminoacidi di 166, ed è implicato in Aplastic anemia.
Offriamo 13 proteine Interferon gamma
Informazioni su geni e proteine
Riepilogo UniProt
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Sommario di Entrez
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.
Specificità del tessuto
Released primarily from activated T lymphocytes.
Coinvolgimento nella malattia
Aplastic anemia: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.
Somiglianze di sequenza
Belongs to the type II (or gamma) interferon family.
Modifica post-translazionale
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
Posizione cellulare
Secreted.
