IL13 è un gene codificato dal simbolo IL13. Comunemente indicato anche come: Interleukin-13; IL-13; NC30. IL13 ha una massa di 15.82kDa, una lunghezza di amminoacidi di 146, ed è implicato in Allergic rhinitis.
Offriamo 11 proteine IL13
Informazioni su geni e proteine
Riepilogo UniProt
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).
Sommario di Entrez
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
Coinvolgimento nella malattia
Allergic rhinitis: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
Somiglianze di sequenza
Belongs to the IL-4/IL-13 family.
Posizione cellulare
Secreted.
