Granzyme B è un gene codificato dal simbolo GZMB. Comunemente indicato anche come: C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMB; CGL1; CSPB; CTLA1; GRB. Granzyme B ha una massa di 27.72kDa e una lunghezza di amminoacidi di 247.
Offriamo 6 proteine Granzyme B
Informazioni su geni e proteine
Riepilogo UniProt
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Sommario di Entrez
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.
Somiglianze di sequenza
Belongs to the peptidase S1 family. Granzyme subfamily.
Posizione cellulare
Cytoplasmic granule.
Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
