CTGF è un gene codificato dal simbolo CCN2. Altri nomi includono: CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth factor-binding protein 8; IBP-8; CCN2; HCS24; IGFBP8. CTGF ha una massa di 38.09kDa e una lunghezza di amminoacidi di 349.
Offriamo 7 proteine CTGF
Informazioni su geni e proteine
Riepilogo UniProt
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Sommario di Entrez
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
Specificità del tessuto
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Somiglianze di sequenza
Belongs to the CCN family.
Posizione cellulare
Secreted > Extracellular space > Extracellular matrix. Secreted.
