CNTF è un gene codificato dal simbolo CNTF. È noto anche come Ciliary neurotrophic factor. CNTF ha una massa di 22.93kDa e una lunghezza di amminoacidi di 200.
Offriamo 8 proteine CNTF
Informazioni su geni e proteine
Riepilogo UniProt
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Sommario di Entrez
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
Specificità del tessuto
Nervous system.
Somiglianze di sequenza
Belongs to the CNTF family.
Posizione cellulare
Cytoplasm.
