CD14 è un gene codificato dal simbolo CD14. È noto anche come Monocyte differentiation antigen Myeloid cell-specific leucine-rich glycoprotein. CD14 ha una massa di 40.08kDa e una lunghezza di amminoacidi di 375.
Offriamo 7 proteine CD14
Informazioni su geni e proteine
Riepilogo UniProt
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
Sommario di Entrez
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein.
Specificità del tessuto
Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Modifica post-translazionale
N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Posizione cellulare
Cell membrane. Secreted. Membrane raft. Golgi apparatus.
Secreted forms may arise by cleavage of the GPI anchor.
